期刊
JOURNAL OF MEDICAL GENETICS
卷 37, 期 10, 页码 782-784出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jmg.37.10.782
关键词
FMR2; FMR3; FRAXE; mental retardation
We have identified a novel gene, FMR3, originating from the FRAXE CpG island. The FMR3 gene is transcribed from the opposite strand to the FMR2 gene. Analogous to the silencing of the FMR1 and FMR2 genes, FMR3 transcription is extinguished by FRAXE full mutation. Although the role of FMR3 in FRAXE associated mild to borderline mental retardation is not yet clear, lack of expression of FMR3 in FRAXE full mutation males means that the FMR3 gene is potentially involved.
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