期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 213, 期 1-2, 页码 61-63出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1007156732662
关键词
choline acetyl transferase; lipoic acid; thioctic acid; dihydrolipoic acid; enzyme regulation
类别
The observations reported in this article demonstrate that lipoic acid strongly influences the activity of a purified preparation of choline acetyl transferase. The reduced form, dihydrolipoic acid, is a powerful activator of the enzyme while lipoic acid itself has an inhibitory effect and counteracts the stimulatory effect of dihydrolipoic acid. It is proposed that dihydrolipoic acid serves an essential function in the action of this enzyme and that the ratio of reduced to oxidized lipoic acid in the cell may play an important role in the regulation of the activity of the enzyme. The implications of these findings for cell function and acetyl choline formation are discussed.
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