期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 37, 期 5, 页码 834-839出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b14-00012
关键词
inhalation isoflurane anesthesia; pentobarbital; hemodynamic status; blood gas; rat
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (KAKENHI)
The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal anesthesia with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) and determination of blood oxygen saturation (SPO2) levels. Following inhalation anesthesia, heart rate (BR) and SPO2 were acceptable while pentobarbital anesthesia decreased HR and SPO2, significantly. This indicates that inhalation anesthesia is more preferable than pentobarbital anesthesia when evaluating cardiovascular factors. Additionally, pentobarbital significantly increased HR variability (HRV), suggesting a regulatory effect of pentobarbital on the autonomic nervous system, and resulted in a decreased response of the baro-reflex system. Propranolol or atropine had limited effects on ECG recording following pentobarbital anesthesia. Taken together, these data suggest that inhalation anesthesia is suitable for conducting hemodynamic analyses in the rat.
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