期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 35, 期 9, 页码 1568-1573出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b12-00461
关键词
apoptosis; ginsenoside; high glucose; cytokine; diabetes
资金
- Grant of the New Century Excellent Research Award Program from Ministry of Education of the People's Republic China [NECT-10-0141]
Apoptosis is the main form of beta-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect beta-cells from high glucose/cytokine-induced pancreatic beta-cell apoptosis via inhibiting nitric oxide (NO) production and regulating apoptosis-related genes. Among these genes, Bax, Fas and Caspase-3 gene expressions were up-regulated by high glucose, whereas only Bax and Caspase-3 gene expression were elevated by cytokines. In these two stimuli-induced apoptotic cells, Rg1 down-regulated Fas gene expression, while Rb1 decreased Caspase-3 gene expression. As a conclusion, Fas signal pathway and mitochondria stress is mostly related to anti-diabetes function of ginsenoside Rg1, while Caspase-3 pathway is essential when Rb1 is present.
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