期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 35, 期 2, 页码 260-264出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.35.260
关键词
gold nanoparticle; glycation; collagen; dermis; aging
资金
- Ministry for Food, Agriculture, Forestry and Fisheries, Repulic of Korea (IPET) [109140032SB010]
Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3 +/- 4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.
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