期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 35, 期 11, 页码 2097-2101出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b12-00633
关键词
hybrid liposome; colon carcinoma; apoptosis
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20107007, 23107731, 23300173]
- Grants-in-Aid for Scientific Research [20107001, 23300173, 24656509, 20107007] Funding Source: KAKEN
New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C-12(EO)(21)) and O,O'-ditetradecanoyl-N-(alpha-trimethylammonioacectyl) diethanolamine chloride (2C(14)ECl) were produced. Cationic HLs were smaller and more stable than pure DMPC liposomes. It is noteworthy that cationic HLs could remarkably inhibit the growth of human co on cancer (HCT116) cells along with apoptosis in vitro for the first time in this study.
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