期刊
PROTEIN SCIENCE
卷 9, 期 10, 页码 1930-1934出版社
WILEY
DOI: 10.1110/ps.9.10.1930
关键词
aminopeptidase Y; cell wall-associated serine protease; transferrin receptor; vacuolar receptor
We have identified a similarity between the apical domain of the human transferrin receptor and several other protein families. This domain is found associated with two different families of peptidases. Therefore, we term it the PA domain for protease-associated domain. The PA domain is found inserted within a loop of the peptidase domain of family M8/M33 zinc peptidases. The PA domain is also found in a vacuolar sorting receptor and a ring finger protein of unknown function that may be a cell surface receptor. The PA domain may mediate substrate determination of peptidases or form protein-protein interactions.
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