期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 34, 期 11, 页码 1769-1772出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.34.1769
关键词
Saururus chinensis; manassantin A; 5-lipoxygenase; cytosolic phospholipase A(2); mitogen-activated protein kinase; bone marrow-derived mast cell
资金
- Fisheries Technology Development Program
- Ministry for Food, Agriculture, Forestry and Fisheries of Korean government
- Yeungnam University
In this study, manassantin A (Man A), an herbal medicine isolated from Saururus chinensis (S. chinensis), markedly inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C-4 (LTC4) generation in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To investigate the molecular mechanisms underlying the inhibition of LTC4 generation by Man A, we assessed the effects of Man A on phosphorylation of cytosolic phospholipase A(2) (cPLA(2)) and mitogen-activated protein kinases (MAPKs). Inhibition of LTC4 generation by Man A was accompanied by a decrease in cPLA(2) phosphorylation, which occurred via the MAPKs including extracellular signal-regulated protein kinase-1/2 (ERK1/2) as well as p38 and c-Jun N-terminal kinase (JNK) pathways. Taken together, the present study suggests the Man A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases.
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