期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 33, 期 5, 页码 912-916出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.912
关键词
piperine; piplartine; metalloporphyrin; biomimetic oxidation; mass spectrometry
资金
- CAPES
- FAPESP [09/51812, 07/54241-8]
- CNPq
- INCT-if
Synthetic metalloporphyrins, in the presence of monooxygen donors, are known to mimetize various reactions of cytochrome P450 enzymes systems in the oxidation of drugs and natural products. The oxidation of piperine and piplartine by iodosylbenzene using iron(III) and manganese(III) porphyrins yielded mono- and dihydroxylated products, respectively. Piplartine showed to be a more reactive substrate towards the catalysts tested. The structures of the oxidation products were proposed based on electrospray ionization tandem mass spectrometry.
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