Evolutionary changes in mutation rates and spectra and their influence on the adaptation of pathogens

The evolutionary tuning of mutational processes may play a key role in prokaryotic evolution, particularly among pathogens. In this paper we review the evidence that genetic systems controlling the rate and spectrum of heritable mutations have evolved to optimize levels of adaptive variation and rates of genetic change. (C) 2000 Editions scientifiques et medicales Elsevier SAS.