期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 33, 期 4, 页码 598-603出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.598
关键词
piperine; calcium oscillation; spontaneous synaptic current; spontaneous excitatory postsynaptic current; glutamate-induced excitotoxicity; hippocampal neuron
资金
- Ministry of Science and Technology of China [2005CB522800, 2004CB318101]
- National Nature Science Foundation of China [30621004]
- Tsinghua-Yue-Yuan Medical Sciences Fund
It was previously reported that piperine (PIP) significantly blocks convulsions induced by intracerebroventricular injection of threshold doses of kainate, but had no or only slight effects on convulsions induced by L-glutamate, N-methyl-D-aspartate and guanidinosuccinate. In traditional Chinese medicine, black pepper has been used for epileptic treatment; however, the exact mechanism is still unclear. We reported here in that appropriate concentration of PIP effectively inhibites the synchronized oscillation of intracellular calcium in rat hippocampal neuronal networks and represses spontaneous synaptic activities in terms of spontaneous synaptic currents (SSC) and spontaneous excitatory postsynaptic currents (sEPSC). Moreover, pretreatment with PIP expects protective effect on glutamate-induced decrease of cell viability and apoptosis of hippocampal neurons. These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca2+ overloading.
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