期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 33, 期 3, 页码 346-350出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.346
关键词
fat specific protein 27; peroxisome proliferator-activated receptor; fatty liver
资金
- ONO Medical Research Foundation
- Takeda Science Foundation
- Suzuken Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Fat specific protein 27 (FSP27) was originally isolated by screen for genes specifically expressed in fully differentiated mouse adipocytes. FSP27 and cell death-inducing DFF45-like effector C (CIDEC), the human homologue of FSP27, belong to the CIDE family. The FSP27 in adipocytes is-as recently reported to be a lipid droplet (LD)-associated protein, that promotes the formation of unilocular LDs. An FSP27 knockout mouse demonstrated lean phenotypes with atrophic adipose (issue as a result of high-energy expenditure; this mouse line was also resistant to diet-induced obesity and insulin resistance. Interestingly, FSP27 was also expressed in the steatoic liver of a type II diabetes model mouse. The expression of FSP27 was markedly decreased in livers lacking the nuclear receptor peroxisome proliferator-activated receptor gamma. Forced expression of FSP27 in hepatocytes in vitro or in vivo led to an increase of LD through increased triglyceride levels. The current status of the physiological roles of FSP27/CIDEC in adipose tissue and liver are discussed along with its significance as a factor involved in the development of metabolic disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据