期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 30, 期 2, 页码 199-211出版社
WILEY
DOI: 10.1002/jbmr.2446
关键词
BONE MINERAL DENSITY (BMD); OBSTRUCTIVE SLEEP APNEA (OSA); NOCTURNAL HYPOXIA; FRACTURE; SLEEP; SLEEP LOSS; CIRCADIAN RHYTHM; BONE REMODELING; REVIEW
资金
- NIH [T32DK007674-20, K24-HL076446, R01 AR045548]
- NASA [NNX1OAR1OG]
- National Institutes of Health via the National Institute on Aging (NIA) [U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, UL1 TR000128]
- National Institutes of Health via the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, UL1 TR000128]
- National Institutes of Health via the NIH Roadmap for Medical Research [U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, UL1 TR000128]
Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adultsa section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep-disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture. (c) 2015 American Society for Bone and Mineral Research
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