期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 10, 期 5, 页码 518-527出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00125-1
关键词
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Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering longstanding questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are crucial to the expression and regulation of the biological functions of glycosaminoglycans in development and pathophysiology.
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