期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 406, 期 1, 页码 159-162出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00624-5
关键词
leptin; 5-HTP (5-hydroxytryptophan); 5-HT (5-hydroxytryptamine, serotonin); benserazide; (mouse)
Effects of peripheral and central injections of a serotonin (5-hydroxytryptamine, 5-HT) precursor, 5-hydroxytryptophan (5-HTP), on serum leptin levels were studied in mice. Intracerebroventricular (i.c.v.) injection of 5-HTP or 5-HT did not increase serum leptin levels, although the peripheral injection of 5-HTP elicited an apparent hyperleptinemia. The elevation of serum leptin levels in mice induced by the peripheral injection of 5-HTP was inhibited by pretreatment with the peripheral aromatic amino acid decarboxylase inhibitor, benserazide. Furthermore, the peripheral injection of 5-HT increased serum leptin levels. These results suggest that the hyperleptinemia following systemic injection of 5-HTP is elicited by 5-HT formed in the peripheral system. (C) 2000 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据