期刊
SCIENCE
卷 290, 期 5489, 页码 134-138出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5489.134
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资金
- NIAID NIH HHS [R37AI29673] Funding Source: Medline
- NIDDK NIH HHS [F32DK09940, DK56894] Funding Source: Medline
Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. This effect is mediated, at least in part, through the direct suppression of peroxisome proliferator-activated receptor gamma. GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition.
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