期刊
NEUROSCIENCE LETTERS
卷 292, 期 2, 页码 137-141出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01446-4
关键词
autoimmunity; encephalomyelitis; demyelinating diseases; multiple sclerosis; blood-brain barrier; uric acid; nitric oxide; peroxynitrite
Peroxynitrite (ONOO-), the product of nitric oxide (NO.) and superoxide (O-2(-.)), is believed to be a major contributor to immunotoxicity when produced by activated cells expressing inducible nitric oxide synthase (iNOS). Uric acid (UA) is a natural scavenger of ONOO- that is present at high levels in the sera of humans and other higher order primates relative to most lower mammals. We have previously shown that UA treatment is therapeutic in experimental allergic encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). In this study we have examined the effect of UA therapy on the dynamics of the appearance of iNOS-positive cells in central nervous system (CNS) tissue of mice subjected to the stimuli that cause EAE. The results indicate that UA prevents activated monocytes from entering CNS tissue where they may contribute to the pathogenesis of MS and other CNS diseases. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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