期刊
ONCOGENE
卷 19, 期 43, 页码 4954-4960出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203870
关键词
HTLV; leukemogenesis; adult T cell leukemia; genetic instability
Adult T cell leukemia (ATLL) develops in 3-5% of HTLV-1 carriers after a long period of latency during which a persistent polyclonal expansion of HTLV-1 infected lymphocytes is observed in all individuals. This incubation period is significantly shortened in HTLV-1 carrier with Strongyloides stercoralis (Ss) infection, suggesting that Ss could be a cofactor of ATLL, As an increased T cell proliferation at the asymptomatic stage of HTLV-1 infection could increase the risk of malignant transformation, the effect of Ss infection on infected T lymphocytes was assessed in vivo in HTLV-1 asymptomatic carriers. After real-time quantitative PCR, the mean circulating HTLV-1 proviral load was more than five times higher in HTLV-1 carriers with stongyloidiasis than in HTLV-1+ individuals without Ss infection (P < 0,009), This increased proviral load was found to result from the extensive proliferation of a restricted number of infected clones, i,e, from oligoclonal expansion, as evidenced by the semiquantitative amplification of HTLV-1 flanking sequences. The positive effect of Ss on clonal expansion was reversible under effective treatment of strongyloidiasis in one patient with parasitological cure whereas no significant modification of the HTLV-1 replication pattern was observed in an additional case with strongyloidiasis treatment failure. Therefore, Ss stimulates the oligoclonal proliferation of HTLV-1 infected cells in HTLV-1 asymptomatic carriers in vivo, This is thought to account for the shortened period of latency observed in ATLL patients with strongyloidiasis.
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