期刊
SCIENCE
卷 290, 期 5490, 页码 341-344出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5490.341
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资金
- PHS HHS [38496] Funding Source: Medline
Asymmetric Localization of proteins plays a key role in many cellular processes, including cell polarity and cell fate determination. Using DNA microarray analysis, we identified a plasma membrane protein-encoding mRNA (IST2) that is transported to the bud tip by an actomyosin-based process. mRNA localization created a higher concentration of IST2 protein in the bud compared with that of the mother cell, and this asymmetry was maintained by a septin-mediated membrane diffusion barrier at the mother-bud neck. These results indicate thar yeast creates distinct plasma membrane compartments, as has been described in neurons and epithelial cells.
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