期刊
BIOINORGANIC CHEMISTRY AND APPLICATIONS
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/325873
关键词
-
资金
- Department of Science and Technology, Government of India
Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (A beta) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers to beta-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.
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