期刊
BIOCHEMICAL PHARMACOLOGY
卷 60, 期 8, 页码 1179-1184出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0006-2952(00)00384-1
关键词
cyclin A; transcription; CREB/ATF; adhesion
Several types of cyclins have been identified and among these, cyclin A2 is synthesized in somatic cells at the onset of DNA synthesis as well as during the G2/M transition associated with cyclin-dependent protein kinases 1 and 2. Modulation of cyclin A transcription is due to the interplay between a cell cycle-dependent periodic relief of a transcriptional repression and signals transduced through adenosine 3',5'-cyclic monophosphate, transforming growth factor-beta, and the integrin-mediated pathways. Using primary mouse embryonic fibroblasts from embryos where the genes coding for the protein responsible for susceptibility to retinoblastoma (pRB) and the related p107 and p130 proteins had been individually inactivated, we showed that cyclin A is a functional target of pRB-mediated cell cycle arrest. The factors involved are discussed. BIOCHEM PHARMACOL 60;8:1179-1184, 2000. (C) 2000 Elsevier Science Inc.
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