期刊
BIOINORGANIC CHEMISTRY AND APPLICATIONS
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2010/854514
关键词
-
资金
- University of Mysore, Mysore
- UGC-New Delhi
Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino) isoindoline-1,3-dione (L-1), and 4-(4-hydroxy-3-methoxy-benzylideneamino-N-(pyrimidin-2-yl) benzenesulfonamide (L-2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.
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