期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 528, 期 2, 页码 339-348出版社
WILEY
DOI: 10.1111/j.1469-7793.2000.00339.x
关键词
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资金
- NINDS NIH HHS [NS30045, NS23061, R01 NS030045] Funding Source: Medline
1. The effect of inflammation on the excitability and the level of substance P (XP) in cat mechanoreceptive C and A delta dorsal root ganglion (DRG) neurons were studied in vivo using intracellular recording and immunocytochemical techniques. 2. Following injections of carrageenan (Carg) into the cat hindpaw, the percentage of C neurons exhibiting spontaneous activity increased from 7.2 to 20.7% and the percentage of AS neurons increased from 6.9 to 18.6%. In contrast to most cells from normal, cats, which fired regularly below 10 Hz, many cells from Carg-treated cats fired at higher frequencies or in bursts. 3. Inflammation (Carg treatment) also depolarized membrane potentials, increased membrane input resistance, caused the disappearance of inward rectifying currents and lowered the mean current thresholds of tibial nerve-evoked responses in DRG neurons. 4. With inflammation, the percentage of C or A delta neurons responding to lon threshold mechanoreceptive stimuli increased (C neurons: normal, 13%; inflamed, 41%, A delta neurons: normal, 13 %; inflamed, 39 %), while the percentage of C or A delta neurons responding to high threshold mechanoreceptive stimuli remained unchanged. 5. Some receptive field (RF)-responsive cells were injected with Lucifer Yellow and their XP immunoreactivity was determined. Following Carg treatment, substantially higher percentages of RF-responsive cells were XP positive (C neurons: normal, 35.7%; inflamed, 60%; A delta neurons: normal, 18.2%; inflamed, 66.7%). 6. These combined increases in the excitability of DRG neurons and SP-containing RF responsive neurons could lead to sensitization of sensory neurons, thus contributing to the development of hyperalgesia.
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