期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 122, 期 41, 页码 9968-9976出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0020355
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As described in the preceding two papers, our interest in the construction of natural and natural product-like libraries for chemical biology studies led to the development of a new solid-phase cycloloading strategy for the construction of substituted benzopyrans. Herein, we report a parallel solution-phase method that facilitates the enhancement of both the size and diversity of these non-oligomeric benzopyran libraries using the libraries from libraries principle. We examine the rationale behind the use of this tandem strategy to construct discrete small molecule libraries, and describe the development of a polymer-assisted solution-phase (PASP) methodology necessary to effect the required transformations. Once developed, this chemistry is applied to two demonstration libraries.
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