期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
卷 1482, 期 1-2, 页码 9-24出版社
ELSEVIER
DOI: 10.1016/S0167-4838(00)00148-5
关键词
lipocalin; fatty acid binding protein; avidin; structural comparison; characteristic motif; protein superfamily
Lipocalins are remarkably diverse at the sequence level yet have highly conserved structures. Most lipocalins share three characteristic conserved sequence motifs - the kernel lipocalins - while others are more divergent family members - the outlier lipocalins - typically sharing only one or two. This classification is a useful tool for analysing the family, and within these large sets are smaller groups sharing much higher levels of sequence similarity. The lipocalins are also part of a larger protein superfamily: the calycins, which includes the fatty acid binding proteins, avidins, a group of metalloproteinase inhibitors, and triabin. The superfamily is characterised by a similar structure (a repeated +1 topology beta -barrel) and by the conservation of a remarkable structural signature. (C) 2000 Elsevier Science B.V. All rights reserved.
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