期刊
BIOINFORMATICS
卷 30, 期 22, 页码 3279-3280出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btu510
关键词
-
类别
资金
- Platform for Drug Discovery, Informatics and Structural Life Science, MEXT, Japanese Government
Motivation: Kotai Antibody Builder is a Web service for tertiary structural modeling of antibody variable regions. It consists of three main steps: hybrid template selection by sequence alignment and canonical rules, 3D rendering of alignments and CDR-H3 loop modeling. For the last step, in addition to rule-based heuristics used to build the initial model, a refinement option is available that uses fragment assembly followed by knowledge-based scoring. Using targets from the Second Antibody Modeling Assessment, we demonstrate that Kotai Antibody Builder generates models with an overall accuracy equal to that of the best-performing semi-automated predictors using expert knowledge.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据