期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 65, 期 21, 页码 7187-7194出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0056186
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资金
- NIGMS NIH HHS [R01GM57123] Funding Source: Medline
Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative td Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.
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