期刊
MOLECULAR BRAIN RESEARCH
卷 82, 期 1-2, 页码 133-136出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(00)00182-0
关键词
apomorphine; bromocriptine; tyrosine hydroxylase; nigrostriatal dopaminergic neurons; feedback inhibition
Levels of tyrosine hydroxylase (TH) and TH mRNA were measured after administration of dopamine agonists for a long period of time to elucidate the long-term feedback inhibition of dopamine synthesis in nigrostriatal dopaminergic neurons. Continuous infusion, which desensitized presynaptic dopamine receptors, but not repeated administration, down-regulated TH and TH mRNA levels. This suggests levels of TH protein and mRNA are only feedback inhibited by the continuous stimulation of postsynaptic dopamine receptors. (C) 2000 Elsevier Science B.V. All rights reserved.
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