期刊
CIRCULATION RESEARCH
卷 87, 期 9, 页码 728-730出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.87.9.728
关键词
hematopoietic stem cell; angiogenesis; endothelial cell
资金
- NHLBI NIH HHS [HL18645, HL03174] Funding Source: Medline
Granulation tissue formation is an example of new tissue development in an adult. its rich vascular network has been thought to derive via angiogenic sprouting and extension of preexisting vessels from the surrounding tissue. The possibility that circulating cells of hematopoietic origin can differentiate into vascular endothelial cells (ECs) in areas of vascular remodeling has recently gained credibility. However, no quantitative data have placed the magnitude of this contribution into a physiological perspective. We have used hematopoietic chimeras to determine that 0.2% to 1.4% of ECs in vessels in control tissues derived from hematopoietic progenitors during the 4 months after irradiation and hematopoietic recovery. By contrast, 8.3% to 11.2% of ECs in vessels that developed in sponge-induced granulation tissue during 1 month derived from circulating hematopoietic progenitors. This recruitment of circulating progenitors to newly forming vessels would be difficult to observe in standard histological studies, but it is large enough to be encouraging for attempts to manipulate this contribution for therapeutic gain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据