期刊
BIOINFORMATICS
卷 30, 期 14, 页码 2009-2017出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btu156
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资金
- Deutsche Forschungsgemeinschaft [STA 850/15]
- Austrian Science Fund (FWF) [M1618-N28]
- University of Vienna
- Austrian Science Fund (FWF) [M1619] Funding Source: Austrian Science Fund (FWF)
Motivation: RNA folding is a complicated kinetic process. The minimum free energy structure provides only a static view of the most stable conformational state of the system. It is insufficient to give detailed insights into the dynamic behavior of RNAs. A sufficiently sophisticated analysis of the folding free energy landscape, however, can provide the relevant information. Results: We introduce the Basin Hopping Graph (BHG) as a novel coarse-grained model of folding landscapes. Each vertex of the BHG is a local minimum, which represents the corresponding basin in the landscape. Its edges connect basins when the direct transitions between them are 'energetically favorable'. Edge weights endcode the corresponding saddle heights and thus measure the difficulties of these favorable transitions. BHGs can be approximated accurately and efficiently for RNA molecules well beyond the length range accessible to enumerative algorithms.
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