期刊
CANCER LETTERS
卷 159, 期 2, 页码 113-117出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(00)00464-X
关键词
strawberries; mouse; lung; benzo[a]pyrene; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; chemoprevention
类别
In the present study, we examined the ability of lyophilized strawberries in the diet to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- and benzo[a]pyrene (B[a]P)-induced lung tumorigenesis in the A/J mouse. Groups of 20 mice were administered purified AIN-76A diet containing 10% lyophilized strawberries 1 week before carcinogen dosing, and for the duration of the study. NNK was administered by i.p. injection in five. 0.414 mg doses. B[a]P was administered by gavage in five, 0.2 mg doses. At 20 weeks, there were no significant differences in tumor incidence or tumor multiplicity between the NNK + 10% lyophilized strawberry group and the NNK control group. Similarly, at 13 weeks, there were no differences in tumorigenesis between the B[a]P + 10% lyophilized strawberry group and the B[a]P control group. Therefore, lyophilized strawberries at 10% in the diet failed to inhibit NNK- and B[a]P-induced mouse lung tumorigenesis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据