期刊
CANCER LETTERS
卷 159, 期 2, 页码 189-195出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(00)00551-6
关键词
chitosan oligomers; nitric oxide; tumor necrosis factor-alpha; tumoricidal activity; macrophages
类别
The effects of water-soluble chitosan oligomers (WSCO) on the synthesis of nitric oxide (NO) by murine peritoneal macrophages and on macrophage-mediated cytotoxicity towards murine fibrosarcoma Meth A cells were investigated. WSCO alone had no effect on NO synthesis and killing of tumor cells. However, treatment of macrophages with a combination of WSCO and interferon-gamma (IFN-gamma) synergically increased NO synthesis and enhanced killing of tumor cells. The synergism between IFN-gamma, and WSCO in NO synthesis and tumoricidal activity was mainly dependent on increased secretion of tumor necrosis factor-alpha by WSCO. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.
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