期刊
BIOINFORMATICS
卷 29, 期 15, 页码 1888-1889出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btt293
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资金
- Mayo Foundation
- US National Institute of Health [R21 GM86689, P30 CA168524, P20 GM103418]
We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and detect intratumor heterogeneity based on next-generation sequencing data of paired tumor-normal tissue samples, which uses finite mixture modeling methods. We demonstrate our approach using simulated data and discuss its performance under varying conditions.
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