期刊
BIOINFORMATICS
卷 29, 期 24, 页码 3109-3112出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btt542
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类别
资金
- Fulbright foundation
- School of Biology, Georgia Institute of Technology
- Alfred P. Sloan Research Fellowship
Motivation: It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon. Results: To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4(+) T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4(+) T cells.
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