期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 111, 期 1-2, 页码 109-121出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(00)00371-4
关键词
astrocytes; chemokine receptors; chemotaxis; inflammatory response
资金
- NCI NIH HHS [CA67416] Funding Source: Medline
- NINDS NIH HHS [NS37284] Funding Source: Medline
Multiple lines of evidence are presented characterizing the functional expression of chemokine receptors CXCR4, CCR1, CCR5, and CX3CR1 on astrocytes. Most of these receptors are expressed at low levels and may only be detectable on a subset of cells during disease or following cytokine induction. The expression of CXCR2, CCR2, CCR3, CCR10, CCR11, and several orphan receptors associated with HIV-1 infection has also been proposed. The appearance of several chemokine receptors implies a wider role for chemokines in the regulation of central nervous system functions. Available evidence indicates that selected chemokines induce further chemokine synthesis in astrocytes providing a mechanism to amplify inflammatory responses in the central nervous system. (C) 2000 Elsevier Science B.V. All rights reserved.
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