期刊
JOURNAL OF INFECTIOUS DISEASES
卷 182, 期 5, 页码 1553-1556出版社
UNIV CHICAGO PRESS
DOI: 10.1086/315870
关键词
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Concentrations of serum anti-Haemophilus influenzae type b (anti-Hib) capsular polysaccharide (CPS) greater than or equal to0.15 and greater than or equal to1.0 mug/mL are widely used as surrogates for protection against invasive Hib disease. However, the relationship between serum anti-Hib CPS following immunization and protection against colonization is not known, making it difficult to evaluate new Hib vaccines or combination vaccines. In the Dominican Republic, nasopharyngealswabs were collected from 546 9-month-old infants who had received Hib conjugate vaccine at ages 2, 4, and 6 months and from 600 unvaccinated infants of the same age. The prevalence of Hib colonization was lower among vaccinated infants than among unvaccinated infants (0.9% vs. 2,3%), Among vaccinated infants, protection against colonization was significantly correlated with anti-Hib CPS concentrations greater than or equal to5 mug/mL 1 month following the third dose of vaccine. These results suggest that the concentration of serum anti-Hib CPS needed for protection against colonization is greater than that needed for protection for invasive disease.
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