期刊
BIOINFORMATICS
卷 28, 期 23, 页码 3153-3154出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bts588
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资金
- National Institutes of Health [CA009363, GM083084, RR021967, GM103552, UL1RR025005]
Frozen robust multiarray analysis (fRMA) is a single-array preprocessing algorithm that retains the advantages of multiarray algorithms and removes certain batch effects by downweighting probes that have high between-batch residual variance. Here, we extend the fRMA algorithm to two new microarray platforms-Affymetrix Human Exon and Gene 1.0 ST-by modifying the fRMA probe-level model and extending the frma package to work with oligo ExonFeatureSet and GeneFeatureSet objects.
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