期刊
BIOINFORMATICS
卷 28, 期 15, 页码 2064-2066出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bts309
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资金
- German Science Foundation (DFG) [STA 860/2, STA 860/3]
- NSF (National Science Foundation)
- Heidelberg Institute of Theoretical Studies
Motivation: Due to advances in molecular sequencing and the increasingly rapid collection of molecular data, the field of phyloinformatics is transforming into a computational science. Therefore, new tools are required that can be deployed in supercomputing environments and that scale to hundreds or thousands of cores. Results: We describe RAxML-Light, a tool for large-scale phylogenetic inference on supercomputers under maximum likelihood. It implements a light-weight checkpointing mechanism, deploys 128-bit (SSE3) and 256-bit (AVX) vector intrinsics, offers two orthogonal memory saving techniques and provides a fine-grain production-level message passing interface parallelization of the likelihood function. To demonstrate scalability and robustness of the code, we inferred a phylogeny on a simulated DNA alignment (1481 taxa, 20 000 000 bp) using 672 cores. This dataset requires one terabyte of RAM to compute the likelihood score on a single tree.
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