Recreational use of Aminorex and pulmonary hypertension

Pulmonary hypertension has been associated with ingestion of the appetite suppressant aminorex. A similar compound, 4-methyl-aminorex (street names, U-4-E-uh [pronounced euphoria] or ice), is a designer drug with central stimulant activity. This drug was discovered on the property of three individuals with diagnoses of pulmonary hypertension. The association between recreational aminorex manufacture and ingestion and the development of pulmonary hypertension is described.