期刊
JOURNAL OF HYPERTENSION
卷 18, 期 11, 页码 1563-1572出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004872-200018110-00006
关键词
capillaries; hemodynamics; low intensity training; myocardium; skeletal muscle
Objective To investigate mechanisms underlying the training-induced blood pressure-lowering effect we analyzed the hemodynamic responses and morphometric changes of the skeletal muscle microcirculation of spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats during an exercise training program. Design Training (50-60% VO2 max) was performed on a treadmill for 13 weeks and control groups were kept sedentary over the same period of time. Trained and sedentary rats were chronically instrumented for hindlimb flow and arterial pressure (AP) recordings under conscious unrestrained conditions. Gracilis and myocardial muscle samples were obtained for morphometric analysis after transcardiac perfusion of fixative. Results SHR, when compared to WKY presented an elevated blood pressure, an increased relative hindlimb vascular resistance, capillary rarefaction in both gracilis and myocardium and an increased wall-to-lumen ratio of gracilis arterioles. Training increased significantly both capillary density and capillary/fiber ratio in the gracilis and myocardium of WKY and SHR groups, causing a complete reversal of capillary rarefaction in trained SHR, In SHR, training also reduced resting blood pressure and caused normalization of both relative hindlimb vascular resistance and gracilis arterioles wall-to-lumen ratio, Regression analysis revealed strong positive correlation between hindlimb vascular resistance and mean AP (MAP) and between arterioles wall-to-lumen ratio and MAP. Conclusions The results suggest that low-intensity training can significantly reduce pressure in SHR while normalizing both the arteriole morphology anti the resistance of the skeletal muscle microcirculation. J Hypertens 18:1563-1572 (C) 2000 Lippincott Williams & Wilkins.
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