期刊
BIOINFORMATICS
卷 27, 期 24, 页码 3435-3436出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr589
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- Austrian Science Fund (FWF) [P19467-B11, P22725-B11]
- Austrian Science Fund (FWF) [P22725] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 19467, P 22725] Funding Source: researchfish
Sequencing pooled DNA samples (Pool-Seq) is the most cost-effective approach for the genome-wide comparison of population samples. Here, we introduce PoPoolation2, the first software tool specifically designed for the comparison of populations with Pool-Seq data. PoPoolation2 implements a range of commonly used measures of differentiation (FST, Fisher's exact test and Cochran-Mantel-Haenszel test) that can be applied on different scales (windows, genes, exons, SNPs). The result may be visualized with the widely used Integrated Genomics Viewer.
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