期刊
BIOINFORMATICS
卷 27, 期 15, 页码 2153-2155出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr347
关键词
-
类别
资金
- Danish Council for Independent Research
- Natural Sciences (FNU)
- Danish National Research Foundation (Danmarks Grundforskningsfond)
Ancient DNA extracts consist of a mixture of contaminant DNA molecules, most often originating from environmental microbes, and endogenous fragments exhibiting substantial levels of DNA damage. The latter introduce specific nucleotide misincorporations and DNA fragmentation signatures in sequencing reads that could be advantageously used to argue for sequence validity. mapDamage is a Perl script that computes nucleotide misincorporation and fragmentation patterns using next-generation sequencing reads mapped against a reference genome. The Perl script outputs are further automatically processed in embedded R script in order to detect typical patterns of genuine ancient DNA sequences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据