4.7 Article

FR-HIT, a very fast program to recruit metagenomic reads to homologous reference genomes

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BIOINFORMATICS
卷 27, 期 12, 页码 1704-1705

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OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr252

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  1. National Center for Research Resources [R01RR025030, R01HG005978]
  2. National Human Genome Research Institute

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Fragment recruitment, a process of aligning sequencing reads to reference genomes, is a crucial step in metagenomic data analysis. The available sequence alignment programs are either slow or insufficient for recruiting metagenomic reads. We implemented an efficient algorithm, FR-HIT, for fragment recruitment. We applied FR-HIT and several other tools including BLASTN, MegaBLAST, BLAT, LAST, SSAHA2, SOAP2, BWA and BWA-SW to recruit four metagenomic datasets from different type of sequencers. On average, FR-HIT and BLASTN recruited significantly more reads than other programs, while FR-HIT is about two orders of magnitude faster than BLASTN. FR-HIT is slower than the fastest SOAP2, BWA and BWA-SW, but it recruited 1-5 times more reads.

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