期刊
BIOINFORMATICS
卷 27, 期 18, 页码 2601-2602出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr446
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资金
- Broad Sequencing Platform
- Genetics Analysis Platform
- Cancer Genome Atlas
- National Human Genome Research Institute [U24 CA126546]
Here, we present ContEst, a tool for estimating the level of cross-individual contamination in next-generation sequencing data. We demonstrate the accuracy of ContEst across a range of contamination levels, sources and read depths using sequencing data mixed in silico at known concentrations. We applied our tool to published cancer sequencing datasets and report their estimated contamination levels.
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