期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 79, 期 11, 页码 850-857出版社
ELSEVIER GMBH
DOI: 10.1078/0171-9335-00113
关键词
arteriogenesis (collateral artery growth); vascular endothelial growth factor; Monocytes; integrins; cell adhesion molecules
类别
Monocytes play an important role in collateral vessel formation (arteriogenesis) by attaching to activated endothelium and by invading the walls of innate collateral vessels where they produce growth factors. Previous studies have demonstrated that this process fan be promoted by several chemokines and growth factors. In this study we examined the interaction between monocytes and endothelium under stimulation of the angiogenic agent vascular endothelial growth factor (VEGF). We report here the novel finding that VEGF stimulates the expression of the alpha (L)-, alpha (M)- and beta (2)-integrin monomers. In functional assays and by using neutralizing antibodies it was shown that VEGF stimulates adhesion of monocytes to human umbilical vein endothelial cells (HUVEC), and increased transmigration through endothelial monolayers is dependent on interaction of monocyte B-2-integrins with its endothelial counter ligand ICAM-1. Based on these in vitro data we hypothesize that the positive effect of VEGF on arteriogenesis may involve monocyte activation.
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