期刊
JOURNAL OF IMMUNOLOGY
卷 165, 期 9, 页码 5017-5026出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.9.5017
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- NIAID NIH HHS [AI26887] Funding Source: Medline
Efficient peptide presentation by professional APC to naive and effector CD4 T cells in vitro is limited to the first 1-2 days of culture, but is nonetheless optimum for effector expansion and cytokine production. In fact, prolonging Ag presentation leads to high levels of T cell death, decreased effector expansion, and decreased cytokine production by recovered effecters, Despite the absence of Ag presentation beyond day 2, T cell division continues at a constant rate throughout the 4-day culture. The Ag-independent later stage depends on the presence of IL-2, and we conclude optimum effector generation depends on an initial 2 days of TCR stimulation followed by an additional 2 days of Ag-independent, cytokine driven T cell expansion and differentiation.
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