期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 20, 期 21, 页码 8157-8167出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.20.21.8157-8167.2000
关键词
-
资金
- NCI NIH HHS [F32 CA081744, CA09078, R01CA5502, T32 CA009078] Funding Source: Medline
- NHGRI NIH HHS [P01HG0132] Funding Source: Medline
Exposure to carcinogenic alkylating agents, oxidizing agents, and ionizing radiation modulates transcript levels for over one third of Saccharomyces cerevisiae's 6,200 genes. Computational analysis delineates groups of coregulated genes whose upstream regions bear known and novel regulatory sequence motifs, One group of coregulated genes contain a number of DNA excision repair genes (including the MAG1 3-methyladenine DNA glycosylase gene) and a large selection of protein degradation genes. Moreover, transcription of these genes is modulated by the proteasome-associated protein Rpn4, most likely via its binding to MAGI upstream repressor sequence 2-like elements, that turn out to be almost identical to the recently identified proteasome-associated control element (G. Mannhaupt, R. Schnall, V. Karpov, I. Vetter, and H. Feldmann, FEES Lett. 450:27-34, 1999). We have identified a large number of genes whose transcription is influenced by Rpn4p.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据