期刊
BIOINFORMATICS
卷 26, 期 23, 页码 2993-2994出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btq579
关键词
-
类别
资金
- EU [N 226852 (SCALES)]
- Swiss National Foundation [31003A-127465]
- Swiss National Science Foundation (SNF) [31003A_127465] Funding Source: Swiss National Science Foundation (SNF)
SPLATCHE2 is a program to simulate the demography of populations and the resulting molecular diversity for a wide range of evolutionary scenarios. The spatially explicit simulation framework can account for environmental heterogeneity and fluctuations, and it can manage multiple population sources. A coalescent-based approach is used to generate genetic markers mostly used in population genetics studies ( DNA sequences, SNPs, STRs or RFLPs). Various combinations of independent, fully or partially linked genetic markers can be produced under a recombination model based on the ancestral recombination graph. Competition between two populations ( or species) can also be simulated with user-defined levels of admixture between the two populations. SPLATCHE2 may be used to generate the expected genetic diversity under complex demographic scenarios and can thus serve to test null hypotheses. For model parameter estimation, SPLATCHE2 can easily be integrated into an Approximate Bayesian Computation (ABC) framework.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据