期刊
JOURNAL OF IMMUNOLOGY
卷 165, 期 9, 页码 4797-4801出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.9.4797
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- NIAID NIH HHS [AI38339] Funding Source: Medline
- NIAMS NIH HHS [AR42637] Funding Source: Medline
CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. hi this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag, Ph infection of CD1d-deficient (CD1d(-/-)) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to I-ig rapidly down-modulated on spirochetes in vivo. CD1d(-/-) Inice exhibited high-titer Bb-specific IgG2a, an isotype commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Ph-resistant mice with the Ab and disease profile of a susceptible mouse strain.
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