期刊
IMMUNITY
卷 13, 期 5, 页码 621-631出版社
CELL PRESS
DOI: 10.1016/S1074-7613(00)00062-5
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- NCI NIH HHS [CA68675] Funding Source: Medline
We have identified the lymphocyte semaphorin CD100/Sema4D as a CD40-inducible molecule by subtractive cDNA cloning. CD100 stimulation significantly enhanced the effects of CD40 on B cell responses. Administration of soluble CD100 markedly accelerated in vivo antigen-specific antibody responses. CD100 receptors with different binding affinities were detected on renal tubular cells (K-d = similar to1 X 10(-9) M) and lymphocytes (K-d = similar to3 x 10(-7) M) Expression cloning revealed that the CD100 receptor on lymphocytes is CD72, a negative regulator of B cell responsiveness. CD72 thus represents a novel class of semaphorin receptors. CD100 stimulation induced tyrosine dephosphorylation of CD72 and dissociation of SHP-1 from CD72. Our findings indicate that CD100 plays a critical role in immune responses by the novel mechanism of turning off negative signaling by CD72.
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